TY - JOUR
T1 - Premorbid, clinical and cognitive correlates of primary negative symptoms in first-episode psychosis
AU - Chang, Wing Chung
AU - Lau, Charles Fu Chun
AU - Chan, Sherina Suet In
AU - Hui, Christy Lai Ming
AU - Chan, Sherry Kit Wa
AU - Lee, Edwin Ho Ming
AU - Lin, Jingxia
AU - Chen, Eric Yu Hai
N1 - Funding Information:
Author E.Y.H.C. has participated in the paid advisory board for Otsuka, has received educational grant support from Janssen-Cilag, and has received research funding from Astra-Zeneca, Janssen-Cilag, Eli Lilly, Sanofi-Aventis and Otsuka. E.H.M.L has been a member of the paid advisory boards for Eli Lilly and AstraZeneca. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Funding Information:
This study was funded by the Hong Kong Jockey Club Charities Trust ( 21009144 ). The funding body had no involvement in any aspect of the study or manuscript preparation. We thank all the coordinating clinicians and staff from the participating hospitals, clinics and medical records departments for their kind assistance. We are also grateful to the individuals who participated in the study.
Publisher Copyright:
© 2016 Elsevier Ireland Ltd.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/8/30
Y1 - 2016/8/30
N2 - Negative symptoms are a core psychopathological dimension of psychotic disorders. Previous research on primary negative symptoms (PNS) mostly focused on chronic samples. Data regarding premorbid, clinical and cognitive correlates of PNS in the early illness course are limited and inconsistent. In this study, we assessed 355 Hong Kong Chinese adult patients presenting with first-episode psychosis (FEP) to early intervention service with an aim to examine the prevalence of PNS and its relationships with premorbid adjustment, clinical and cognitive profiles. PNS was defined as the presence of clinically significant negative symptoms excluding depression, positive symptoms and extrapyramidal signs. Results showed that 14.6% of patients exhibited PNS at service entry. PNS group had poorer premorbid social functioning, lower level of insight, and worse performance in Modified Wisconsin Card Sorting and digit symbol tests than non-PNS group. Logistic regression analysis showed that premorbid social functioning and digit symbol test score were independently associated with PNS. Our findings thus indicate that PNS are frequently observed in FEP patients. Deficits in proceeding speed, alongside impaired premorbid social functioning, might be specifically related to PNS in the early illness stage.
AB - Negative symptoms are a core psychopathological dimension of psychotic disorders. Previous research on primary negative symptoms (PNS) mostly focused on chronic samples. Data regarding premorbid, clinical and cognitive correlates of PNS in the early illness course are limited and inconsistent. In this study, we assessed 355 Hong Kong Chinese adult patients presenting with first-episode psychosis (FEP) to early intervention service with an aim to examine the prevalence of PNS and its relationships with premorbid adjustment, clinical and cognitive profiles. PNS was defined as the presence of clinically significant negative symptoms excluding depression, positive symptoms and extrapyramidal signs. Results showed that 14.6% of patients exhibited PNS at service entry. PNS group had poorer premorbid social functioning, lower level of insight, and worse performance in Modified Wisconsin Card Sorting and digit symbol tests than non-PNS group. Logistic regression analysis showed that premorbid social functioning and digit symbol test score were independently associated with PNS. Our findings thus indicate that PNS are frequently observed in FEP patients. Deficits in proceeding speed, alongside impaired premorbid social functioning, might be specifically related to PNS in the early illness stage.
KW - Digit symbol test
KW - First-episode psychosis
KW - Premorbid adjustment
KW - Primary negative symptoms
KW - Processing speed
UR - http://www.scopus.com/inward/record.url?scp=84973137909&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2016.05.045
DO - 10.1016/j.psychres.2016.05.045
M3 - Journal article
C2 - 27280524
AN - SCOPUS:84973137909
SN - 0165-1781
VL - 242
SP - 144
EP - 149
JO - Psychiatry Research
JF - Psychiatry Research
ER -
