Predictors of extubation outcomes among extremely and very preterm infants: a retrospective cohort study

Fang He, Dehua Wu, Yi Sun, Yan Lin (Corresponding Author), Xiulan Wen, Andy S.K. Cheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Objective: To explore the clinical or sociodemographic predictors for both successful and failed extubation among Chinese extremely and very preterm infants Methods: A retrospective cohort study was carried out among extremely and very preterm infants born at less than 32 weeks of gestational age (GA). Results: Compared with the infants who experienced extubation failure, the successful infants had higher birth weight (OR 0.997; CI 0.996–0.998), higher GA (OR 0.582; 95% CI 0.499–0.678), a caesarean section delivery (OR 0.598; 95% CI 0.380–0.939), a higher five-minute Apgar score (OR 0.501; 95% CI 0.257–0.977), and a higher pH prior to extubation (OR 0.008; 95% CI 0.001–0.058). Failed extubation was associated with older mothers (OR 1.055; 95% CI 1.013–1.099), infants intubated in the delivery room (OR 2.820; 95% CI 1.742–4.563), a higher fraction of inspired oxygen (FiO2) prior to extubation (OR 5.246; 95% CI 2.540–10.835), higher partial pressure of carbon dioxide (PCO2) prior to extubation (OR 7.820; 95% CI 3.725–16.420), and higher amounts of lactic acid (OR 1.478;95% CI 1.063–2.056). Conclusions: Higher GA, higher pre-extubation pH, lower pre-extubation FiO2 and PCO, and lower age at extubation are significant predictors of successful extubation among extremely and very preterm infants.

Original languageEnglish
JournalJornal de Pediatria
Early online date28 May 2022
Publication statusE-pub ahead of print - 28 May 2022


  • Cohort studies
  • Extremely and very preterm infants
  • Extubation
  • Predictors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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