TY - JOUR
T1 - Predictors of extubation outcomes among extremely and very preterm infants
T2 - a retrospective cohort study
AU - He, Fang
AU - Wu, Dehua
AU - Sun, Yi
AU - Lin, Yan
AU - Wen, Xiulan
AU - Cheng, Andy S.K.
N1 - Funding Information:
This study is funded by Guangzhou Municipal Health Commission (grant #: 20221A011028 ).
Publisher Copyright:
© 2022 Sociedade Brasileira de Pediatria
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Objective: To explore the clinical or sociodemographic predictors for both successful and failed extubation among Chinese extremely and very preterm infants Methods: A retrospective cohort study was carried out among extremely and very preterm infants born at less than 32 weeks of gestational age (GA). Results: Compared with the infants who experienced extubation failure, the successful infants had higher birth weight (OR 0.997; CI 0.996–0.998), higher GA (OR 0.582; 95% CI 0.499–0.678), a caesarean section delivery (OR 0.598; 95% CI 0.380–0.939), a higher five-minute Apgar score (OR 0.501; 95% CI 0.257–0.977), and a higher pH prior to extubation (OR 0.008; 95% CI 0.001–0.058). Failed extubation was associated with older mothers (OR 1.055; 95% CI 1.013–1.099), infants intubated in the delivery room (OR 2.820; 95% CI 1.742–4.563), a higher fraction of inspired oxygen (FiO2) prior to extubation (OR 5.246; 95% CI 2.540–10.835), higher partial pressure of carbon dioxide (PCO2) prior to extubation (OR 7.820; 95% CI 3.725–16.420), and higher amounts of lactic acid (OR 1.478;95% CI 1.063–2.056). Conclusions: Higher GA, higher pre-extubation pH, lower pre-extubation FiO2 and PCO, and lower age at extubation are significant predictors of successful extubation among extremely and very preterm infants.
AB - Objective: To explore the clinical or sociodemographic predictors for both successful and failed extubation among Chinese extremely and very preterm infants Methods: A retrospective cohort study was carried out among extremely and very preterm infants born at less than 32 weeks of gestational age (GA). Results: Compared with the infants who experienced extubation failure, the successful infants had higher birth weight (OR 0.997; CI 0.996–0.998), higher GA (OR 0.582; 95% CI 0.499–0.678), a caesarean section delivery (OR 0.598; 95% CI 0.380–0.939), a higher five-minute Apgar score (OR 0.501; 95% CI 0.257–0.977), and a higher pH prior to extubation (OR 0.008; 95% CI 0.001–0.058). Failed extubation was associated with older mothers (OR 1.055; 95% CI 1.013–1.099), infants intubated in the delivery room (OR 2.820; 95% CI 1.742–4.563), a higher fraction of inspired oxygen (FiO2) prior to extubation (OR 5.246; 95% CI 2.540–10.835), higher partial pressure of carbon dioxide (PCO2) prior to extubation (OR 7.820; 95% CI 3.725–16.420), and higher amounts of lactic acid (OR 1.478;95% CI 1.063–2.056). Conclusions: Higher GA, higher pre-extubation pH, lower pre-extubation FiO2 and PCO, and lower age at extubation are significant predictors of successful extubation among extremely and very preterm infants.
KW - Cohort studies
KW - Extremely and very preterm infants
KW - Extubation
KW - Predictors
UR - http://www.scopus.com/inward/record.url?scp=85131396052&partnerID=8YFLogxK
U2 - 10.1016/j.jped.2022.04.001
DO - 10.1016/j.jped.2022.04.001
M3 - Journal article
C2 - 35640721
AN - SCOPUS:85131396052
SN - 0021-7557
VL - 98
SP - 648
EP - 654
JO - Jornal de Pediatria
JF - Jornal de Pediatria
IS - 6
ER -