Preclinical mouse models of hepatocellular carcinoma: An overview and update

Catherine Yujia Gu, Terence Kin Wah Lee

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Hepatocellular carcinoma (HCC) is by far the most common histological subtype of primary liver cancer. HCC often originates from chronic liver injuries and inflammation, subsequently leading to fibrosis and cirrhosis. Preclinical animal models, especially mice, are viewed as valuable and reliable tools for investigating the molecular processes involved in hepatocarcinogenesis and facilitating the evaluations of the efficacy of novel therapies for HCC. A wide range of mouse models of HCC has been established using various approaches including chemotoxic agents, genetic modifications, special diet administration, and tumor cells transplantation. Choosing a suitable model to represent certain genetic and physiological features of human HCC seems to be crucial. Here, we review the current preclinical mouse models that are frequently used to study HCC.

Original languageEnglish
Article number113042
JournalExperimental Cell Research
Issue number2
Publication statusPublished - 15 Mar 2022


  • Hepatocellular carcinoma
  • Liver cancer
  • Mouse models
  • Preclinical models

ASJC Scopus subject areas

  • Cell Biology


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