Precise temperature control of microfluidic chamber for gas and liquid phase reactions

Alex I.K. Lao, Ming Hung Thomas Lee, I. Ming Hsing, Nancy Y. Ip

Research output: Journal article publicationJournal articleAcademic researchpeer-review

89 Citations (Scopus)


A silicon-based micromachined fluidic chamber with integrated platinum heaters and sensors has been developed and thermally well characterized. This device is highly applicable to both gas and liquid phase reactions that require excellent thermal control. The chamber is thermally isolated from the bulk silicon by a thin silicon nitride membrane resulting in low power consumption. The digitally feedback controlled device demonstrates the ability of precise temperature control, excellent temperature uniformity, rapid heating and cooling. These thermal characteristics are ascribable to the success of miniaturized reaction chamber and Micro Total Analysis Systems (μTAS). In addition, gain scheduling control algorithm in conjunction with normal feedback proportional and integral (PI) scheme was implemented to provide better thermal cycling performance. 3D numerical simulation was also conducted to map the spatial temperature distribution within the miniaturized fluidic device. Simulation results and experimental data show good agreements.
Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalSensors and Actuators, A: Physical
Issue number1
Publication statusPublished - 1 Aug 2000
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering


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