Potentiation of amphetamine-induced locomotor activity following NMDA-induced retrohippocampal neuronal loss in the rat

Kay Yan Benjamin Yee, J. Feldon, J. N.P. Rawlins

Research output: Journal article publicationJournal articleAcademic researchpeer-review

19 Citations (Scopus)

Abstract

The present experiment assessed the locomotor response to a low dose (1 mg/kg) of systemic gemd-amphetamine in rats with cytotoxic lesions of the retrohippocampus (entorhinal and extra-subicular cortices), compared with vehicle-operated shams and unoperated controls. Under spontaneous and saline conditions, both the sham and the lesioned animals were more active than unoperated controls, and they did not differ from each other. Systemic gemd-amphetamine produced increased locomotion in all groups, but this effect was potentiated in animals with retrohippocampal lesions; two control groups did not differ from each other in their response to the drug. The present results are consistent with the suggestion that cell loss within the retrohippocampal region could affect the functional response of nucleus accumbens to amphetamine. The results are discussed in terms of the interaction between the retrohippocampus and nucleus accumbens in the control of mesolimbic dopamine release and the possible implications for schizophrenia.
Original languageEnglish
Pages (from-to)356-364
Number of pages9
JournalExperimental Brain Research
Volume106
Issue number2
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • Amphetamine
  • Locomotion
  • Rat
  • Retrohippocampal cortex
  • Ventral striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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