Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders

Jing Ru Xiao, Chi Wai Do, Chi Ho To

Research output: Journal article publicationReview articleAcademic researchpeer-review

38 Citations (Scopus)

Abstract

2014. Ocular diseases such as cataract, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are the leading causes of blindness. The elderly population is at particular risk of developing one or more of these age-related ocular diseases. By virtue of multiple bioactivities, effort has been made to develop dietary flavonoids as complimentary therapies for ocular disorders. Dietary intake of flavonoids has been reported to reduce the risk of cataract and AMD. This review focuses on the main flavones baicalein, baicalin, and wogonin isolated from the Chinese medicinal herb, Scutellariae radix (SR), which has been widely used in Asian countries for the treatment of many diseases. Interest in SR has grown recently following new findings that suggest multiple routes of therapeutic action. This review will summarize the diverse pharmacological properties, therapeutic roles, and mechanisms of these flavones of SR in cellular and animal models of ocular diseases.
Original languageEnglish
Pages (from-to)605-614
Number of pages10
JournalJournal of Ocular Pharmacology and Therapeutics
Volume30
Issue number8
DOIs
Publication statusPublished - 1 Jan 2014

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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