Potential benefits of probiotics and prebiotics for coronary heart disease and stroke

Haicui Wu, Jiachi Chiou

Research output: Journal article publicationJournal articleAcademic researchpeer-review

59 Citations (Scopus)


Among cardiovascular diseases (CVDs), a major cause of morbidity and mortality worldwide, coronary heart disease and stroke are the most well‐known and extensively studied. The onset and progression of CVD is associated with multiple risk factors, among which, gut mi-crobiota has received much attention in the past two decades. Gut microbiota, the microbial community colonizing in the gut, plays a prominent role in human health. In particular, gut dysbiosis is directly related to many acute or chronic dysfunctions of the cardiovascular system (CVS) in the host. Earlier studies have demonstrated that the pathogenesis of CVD is strongly linked to intestinal microbiota imbalance and inflammatory responses. Probiotics and prebiotics conferring vari-ous health benefits on the host are emerging as promising therapeutic interventions for many dis-eases. These two types of food supplements have the potential to alleviate the risks of CVD through improving the levels of several cardiovascular markers, such as total and low‐density lipoprotein (LDL) cholesterol, high sensitivity C‐reactive protein (hs‐CRP), and certain cytokines involved in the inflammatory response. In this review, we focus mainly on the preventive effects of probiotics and prebiotics on CVD via rebalancing the structural and functional changes in gut microbiota and maintaining immune homeostasis.

Original languageEnglish
Article number2878
Issue number8
Publication statusPublished - Aug 2021


  • CVD
  • Gut microbiota
  • Immune homeostasis
  • Prebiotics
  • Probiotics

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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