Poststroke depression in patients with small subcortical infarcts

Y. Chen, Xiangyan Chen, V.C.T. Mok, W.W.M. Lam, K.S. Wong, W.K. Tang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

12 Citations (Scopus)


Objectives: Small subcortical infarcts (SSIs) can result from small vessel disease (SVD) and intracranial and extracranial large artery disease (LAD). No study has explored poststroke depression (PSD) in different etiological types of SSIs. Methods: Patients with SSIs resulting from LAD and SVD were included in the study. Poststroke depression was evaluated with the 15-item version of the geriatric depression scale (GDS) 3 months after stroke. Results: Of the 127 patients with SSIs, 44 had LAD and 83 had SVD. The LAD group had a significantly higher mean GDS score and higher frequency of PSD (p < 0.05). The etiological type LAD was a significant independent risk factor for PSD. Conclusion: PSD is more common in patients with SSIs resulting from LAD. This suggests that cerebral blood perfusion may play an important role in the development of PSD. © 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)256-260
Number of pages5
JournalClinical Neurology and Neurosurgery
Issue number3
Publication statusPublished - 1 Apr 2009
Externally publishedYes


  • Carotid artery stenosis
  • Depression
  • Intracranial large artery disease
  • MRI
  • Small vessel disease
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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