Post-translational modifications and their applications in eye research (review)

Bing Jie Chen, Chuen Lam, Long Qian Liu, Chi Ho To

Research output: Journal article publicationReview articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

Gene expression is the process by which genetic information is used for the synthesis of a functional gene product, and ultimately regulates cell function. The increase of biological complexity from genome to proteome is vast, and the post-translational modification (PTM) of proteins contribute to this complexity. The study of protein expression and PTMs has attracted attention in the post-genomic era. Due to the limited capability of conventional biochemical techniques in the past, large-scale PTM studies were technically challenging. The introduction of effective protein separation methods, specific PTM purification strategies and advanced mass spectrometers has enabled the global profiling of PTMs and the identification of a targeted PTM within the proteome. The present review provides an overview of current proteomic technologies being applied in eye research, with a particular focus on studies of PTMs in ocular tissues and ocular diseases.
Original languageEnglish
Pages (from-to)3923-3935
Number of pages13
JournalMolecular Medicine Reports
Volume15
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Mass spectrometry
  • Ocular diseases
  • Post-translational modifications
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

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