TY - JOUR
T1 - Porphyrinic Metal-Organic Framework Nanorod-Based Dual-Modal Nanoprobe for Sensing and Bioimaging of Phosphate
AU - Cheng, Changming
AU - Zhang, Ruolin
AU - Wang, Jiuhai
AU - Zhang, Yu
AU - Xiong, Shunshun
AU - Huang, Ying
AU - Yang, Mo
PY - 2020/6/10
Y1 - 2020/6/10
N2 - Herein, a dual-modal fluorescent/colorimetric “Signal-On” nanoprobe based on PCN-222 nanorods (NRs) toward phosphate was proposed for the first time. Due to the high affinity of the zirconium node in PCN-222 NRs for phosphate, the structure collapse of PCN-222 NRs was triggered by phosphate, resulting in the release of the tetrakis(4-carboxyphenyl)porphyrin (TCPP) ligand from PCN-222 NRs as well as the enhancement of fluorescence and absorbance signals. The PCN-222 NR-based nanoprobe could be employed for phosphate detection over a wide concentration range with a detection limit down to 23 nM. The practical application of the PCN-222 NR-based nanoprobe in real samples was evaluated. Moreover, benefitting from the good biocompatibility and water dispersibility of PCN-222 NRs, this nanoprobe was successfully employed in the intracellular imaging of phosphate, revealing its promising application in the biological science. The present work would greatly extend the potential of nanostructured MOFs in the sensing and biological fields.
AB - Herein, a dual-modal fluorescent/colorimetric “Signal-On” nanoprobe based on PCN-222 nanorods (NRs) toward phosphate was proposed for the first time. Due to the high affinity of the zirconium node in PCN-222 NRs for phosphate, the structure collapse of PCN-222 NRs was triggered by phosphate, resulting in the release of the tetrakis(4-carboxyphenyl)porphyrin (TCPP) ligand from PCN-222 NRs as well as the enhancement of fluorescence and absorbance signals. The PCN-222 NR-based nanoprobe could be employed for phosphate detection over a wide concentration range with a detection limit down to 23 nM. The practical application of the PCN-222 NR-based nanoprobe in real samples was evaluated. Moreover, benefitting from the good biocompatibility and water dispersibility of PCN-222 NRs, this nanoprobe was successfully employed in the intracellular imaging of phosphate, revealing its promising application in the biological science. The present work would greatly extend the potential of nanostructured MOFs in the sensing and biological fields.
KW - Signal-On
KW - dual-modal nanoprobe
KW - intracellular imaging
KW - metal-organic framework nanorods
KW - phosphate
UR - http://www.scopus.com/inward/record.url?scp=85086345868&partnerID=8YFLogxK
U2 - https://doi.org/10.1021/acsami.0c06057
DO - https://doi.org/10.1021/acsami.0c06057
M3 - Journal article
VL - 12
SP - 26391
EP - 26398
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 23
ER -