Porphyrinic Metal-Organic Framework Nanorod-Based Dual-Modal Nanoprobe for Sensing and Bioimaging of Phosphate

Changming Cheng, Ruolin Zhang, Jiuhai Wang, Yu Zhang, Shunshun Xiong, Ying Huang (Corresponding Author), Mo Yang (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

52 Citations (Scopus)


Herein, a dual-modal fluorescent/colorimetric “Signal-On” nanoprobe based on PCN-222 nanorods (NRs) toward phosphate was proposed for the first time. Due to the high affinity of the zirconium node in PCN-222 NRs for phosphate, the structure collapse of PCN-222 NRs was triggered by phosphate, resulting in the release of the tetrakis(4-carboxyphenyl)porphyrin (TCPP) ligand from PCN-222 NRs as well as the enhancement of fluorescence and absorbance signals. The PCN-222 NR-based nanoprobe could be employed for phosphate detection over a wide concentration range with a detection limit down to 23 nM. The practical application of the PCN-222 NR-based nanoprobe in real samples was evaluated. Moreover, benefitting from the good biocompatibility and water dispersibility of PCN-222 NRs, this nanoprobe was successfully employed in the intracellular imaging of phosphate, revealing its promising application in the biological science. The present work would greatly extend the potential of nanostructured MOFs in the sensing and biological fields.
Original languageEnglish
Pages (from-to)26391–26398
Number of pages8
JournalACS applied materials & interfaces
Issue number23
Publication statusPublished - 10 Jun 2020


  • Signal-On
  • dual-modal nanoprobe
  • intracellular imaging
  • metal-organic framework nanorods
  • phosphate

ASJC Scopus subject areas

  • General Materials Science


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