Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

Siming Yu; Kar Him Luk; Siu To Cheung; Kevin Wing Hin Kwok; Ka Hing Wong; Tianfeng Chen

doi:10.1039/c8tb01084f

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

Siming Yu
, Kar Him Luk
, Siu To Cheung
, Kevin Wing Hin Kwok
, Ka Hing Wong
, Tianfeng Chen

Research output: Journal article publication › Journal article › Academic research › peer-review

29 Citations (Scopus)

Abstract

Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

Original language	English
Pages (from-to)	5215-5219
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	6
Issue number	32
DOIs	https://doi.org/10.1039/c8tb01084f
Publication status	Published - 1 Jan 2018

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

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10.1039/c8tb01084f

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title = "Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic",

abstract = "Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.",

author = "Siming Yu and Luk, \{Kar Him\} and Cheung, \{Siu To\} and Kwok, \{Kevin Wing Hin\} and Wong, \{Ka Hing\} and Tianfeng Chen",

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AU - Yu, Siming

AU - Luk, Kar Him

AU - Cheung, Siu To

AU - Kwok, Kevin Wing Hin

AU - Wong, Ka Hing

AU - Chen, Tianfeng

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

AB - Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

UR - https://www.scopus.com/pages/publications/85051638399

U2 - 10.1039/c8tb01084f

DO - 10.1039/c8tb01084f

M3 - Journal article

AN - SCOPUS:85051638399

SN - 2050-7518

VL - 6

SP - 5215

EP - 5219

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 32

ER -

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

Abstract

ASJC Scopus subject areas

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