Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

Siming Yu, Kar Him Luk, Siu To Cheung, Kevin Wing Hin Kwok, Ka Hing Wong, Tianfeng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

Original languageEnglish
Pages (from-to)5215-5219
Number of pages5
JournalJournal of Materials Chemistry B
Volume6
Issue number32
DOIs
Publication statusPublished - 1 Jan 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this