The effect of the N-substituents on the polyphosphate ester-(PPE)-catalysed cyclodehydration of a monoester of N-substituted 5-methyl-3-(indol-3′-yl) cyclohex-4-ene-1,2-dicarboxylic acids (41) is presented. Stereoselective synthesis of methyl 9-methyl-6-oxo-5-tosyl-5,6,6aβ,7β,8,10aβ-hexahydroindeno[ 2,1-b]indole-7α-carboxylate (2), the key synthetic intermediate for C(7)-functionalized antifertility agent yuehchukene (YCK) (1) analogues, is described.
|Number of pages||10|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - 1 Dec 1990|
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