Abstract
An aqueous dispersion of polyethylenimine-modified graphene oxide (PEI-GO) was prepared via a one-step synthesis through an epoxy ring-opening reaction. PEI-GO exhibited bacterial growth inhibition activity on methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration as low as 8 μg mL-1. Time-kill curve assay and SYTOX Green assay showed the antibacterial activity and bacteria cell membrane permeability of PEI-GO, respectively. Most importantly, when PEI-GO was employed at 1-2 μg mL-1, a synergistic effect with daptomycin to resensitize daptomycin-resistant MRSA was revealed. A synergistic effect between PEI-GO and daptomycin provides a possible way to increase bacterial killing and reduce the development of daptomycin resistance. The antibacterial activity of PEI-GO is attributed to the damaged cell membrane caused by the sharp edge and chain structure of the PEI-GO nanosheets as well as the high density of amine groups present in the PEI chains. Our results indicate that PEI-GO dispersion has a great potential for clinical pathogenic bacteria treatment.
Original language | English |
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Pages (from-to) | 1811-1818 |
Number of pages | 8 |
Journal | ACS Applied Nano Materials |
Volume | 1 |
Issue number | 4 |
DOIs | |
Publication status | Published - 27 Apr 2018 |
Keywords
- antibacterial
- graphene oxide
- methicillin-resistant Staphylococcus aureus
- polyethylenimine
- synergistic effect
ASJC Scopus subject areas
- General Materials Science