Poly(ethylene glycol) Promoted Reactions of Vinylic Dibromides. Dehydrohalogenation and Palladium(0)-Catalyzed Formal Oxidative Homologation

Pei Li, Howard Alper

Research output: Journal article publicationJournal articleAcademic researchpeer-review

59 Citations (Scopus)


Aldehydes are converted to the homologous acids by a simple two-step procedure involving initial generation of a vinylic dibromide followed by Pd(diphos)2 catalyzed, poly(ethylene glycol) induced reaction with base. This reaction is useful for aromatic and α,β-unsaturated aldehydes and is also applicable to cyclic as well as alkyl aryl ketones. 1-Bromoalkynes are formed in good yields when the vinylic dibromide reaction is effected in the absence of the palladium (0) catalyst.
Original languageEnglish
Pages (from-to)4354-4356
Number of pages3
JournalJournal of Organic Chemistry
Issue number23
Publication statusPublished - 1 Jan 1986
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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