Poly(acrylic acid)-silicon hybrids prepared via a RAFT-mediated process and covalent immobilization of glucose oxidase

Liang Li, Jiayou Ji, Lanyan Li, Keqiang Xia, Songmin Shang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)


A surface modification technique was proposed for the modification of silicon surface with glucose oxidase (GOD). The silicon surface was first graft copolymerized with acrylic acid (AAc) via surface-initiated reversible addition-fragmentation chain-transfer (RAFT)-mediated process. With the aid of a water-soluble carbodiimide, GOD was then covalently immobilized on the silicon surface through the amide linkage between the amino group of GOD and the carboxyl group of the grafted AAc polymer. The changes in the surface composition after polymer grafting and enzyme immobilization on the silicon surface were investigated using X-ray photoelectron spectroscopy (XPS). The amount of GOD immobilized could be varied by changing the thickness of the polymer layer and the immobilization time. The GOD-functionalized silicon hybrids are potential useful in the application of the silicon-based biosensors.
Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Issue number4
Publication statusPublished - 1 Apr 2012


  • glucose oxidase
  • polymer
  • silicon
  • Surface-initiated RAFT

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

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