P,N-Type benzimidazolyl phosphine ligands for the palladium-catalyzed Suzuki coupling of potassium aryltrifluoroborates and aryl chlorides

Shun Man Wong, Chau Ming So, Kin Ho Chung, Chi Him Luk, Chak Po Lau, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)


This study describes the efficacy of P,N-type benzimidazolyl phosphine ligands, which can be easily synthesized from commercially available and inexpensive starting materials. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with potassium aryltrifluoroborates is described. The air stable benzimidazolyl phosphines in combination with a palladium metal precursor provides highly effective catalysts for the Suzuki-Miyaura coupling of unactivated aryl chlorides and can achieve a catalyst loading of only 0.05 mol %.
Original languageEnglish
Pages (from-to)3754-3757
Number of pages4
JournalTetrahedron Letters
Issue number29
Publication statusPublished - 18 Jul 2012


  • P,N-Type ligand
  • Palladium
  • Phosphine
  • Suzuki coupling
  • Trifluoroborate

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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