PM2.5 as a potential risk factor for autism spectrum disorder: Its possible link to neuroinflammation, oxidative stress and changes in gene expression

Ahadullah, Suk yu Yau (Corresponding Author), Hao xian Lu, Tatia M.C. Lee, Hai Guo, Chetwyn C.H. Chan

Research output: Journal article publicationReview articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral deficits including impairments in social communication, social interaction, and repetitive behaviors. Because the etiology of ASD is still largely unknown, there is no cure for ASD thus far. Although it has been established that genetic components play a vital role in ASD development, the influence of epigenetic regulation induced by environmental factors could also contribute to ASD susceptibility. Accumulated evidence has suggested that exposure to atmospheric particulate matter (PM) in polluted air could affect neurodevelopment, thus possibly leading to ASD. Particles with a size of 2.5 μm (PM2.5) or less have been shown to have negative effects on human health, and could be linked to ASD symptoms in children. This review summarizes evidence from clinical and animal studies to demonstrate the possible linkage between PM2.5 exposure and the incidence of ASD in children. An attempt was made to explore the possible mechanisms of this linkage, including changes of gene expression, oxidative stress and neuroinflammation induced by PM2.5 exposure.

Original languageEnglish
Pages (from-to)534-548
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume128
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Autism spectrum disorder
  • Changes of gene expression
  • Neuroinflammation
  • Oxidative stress
  • PM

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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