Plasmon-Enhanced Photocatalytic Activity of Organic Heterostructure for Indoor-Light Antibacterial Therapy

Hui Feng Jiao, Jiaxu Guo, Yuying Cui, Xin Yu, Yunfei Liao, Yiran Ying, Zhongan Li, Kai Yao, Haitao Huang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)


Semiconductor nanomaterials with photocatalytic activity have been considered as potential antibacterial materials against bacterial infection. Noble metal nanoparticles have been developed with semiconductors to promote their photocatalytic activities; however, the incorporation of noble metal NPs brings the risk of toxicity from the heavy metal species, especially for the widely used Ag nanoparticles (AgNPs). Herein, an all-organic chloridized g-C3N4/perylene-3,4,9,10-tetracarboxylic diimide (Cl-CNPD) heterostructure is chosen as a platform, in which the chloridized g-C3N4 provides bonding sites for uniform loading of AgNPs to prepare a plasmonic antibacterial nanocomposite. Benefiting from the in situ implanting approach, plasmon-induced light manipulation from the homodispersed AgNPs enables the nanocomposites to produce more reactive oxygen species (ROS), resulting in an antibacterial efficacy up to 96.1 ± 1.4% and 91.5 ± 1.8% against Staphylococcus aureus (S. aureus) under simulated sunlight (20 mW cm−2) and indoor light (5 mW cm−2) irradiation within 20 min, respectively, much higher than that of the organic heterostructure. Moreover, the strong interaction between the AgNPs and Cl-CNPD not only guarantees negligible toxicity by minimizing Ag leakage, but also shows high durability with unchanged efficacy after challenging bacteria up to five times repeatedly. Therefore, this confined plasmonic-based antibacterial nanocomposite shows great potential as a safe therapeutic system for wound disinfection.

Original languageEnglish
Article number2100202
JournalAdvanced Therapeutics
Issue number2
Publication statusPublished - Feb 2022


  • antibacterial efficacy
  • cytotoxicity
  • in situ implanting
  • indoor light
  • organic heterojunctions
  • plasmonic nanocomposites

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Pharmaceutical Science
  • Genetics(clinical)
  • Biochemistry, medical
  • Pharmacology (medical)


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