TY - JOUR
T1 - Physiotherapy interventions for pain relief in individuals with peripheral neuropathic pain
T2 - A systematic review and meta-analyses of randomized controlled trials
AU - Kannan, Priya
AU - Bello, Umar Muhammad
AU - Winser, Stanley John
N1 - Funding Information:
This review was supported by the Hong Kong Polytechnic University , Dean's reserve fund.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/2
Y1 - 2023/2
N2 - Objective: To evaluate the effectiveness of physiotherapy interventions on peripheral neuropathic pain (pNeP) due to any underlying cause. Methods: Multiple databases were searched from database inception until Dec 2021. Studies on physiotherapy interventions for pain relief assessed using the visual analogue scale among individuals with pNeP of any underlying cause were included. Methodological quality was assessed using the PEDro scale and the quality of the evidence using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. Results: The searches yielded 1498 articles. Seventeen studies met the inclusion criteria and were included in the review. Meta-analysis revealed a significant benefit for laser therapy compared to sham laser on pNeP (weighted mean difference [WMD] −1.27; 95% CI: −2.29 to −0.25; p = 0.01) in people with carpal tunnel syndrome. The pooled analyses revealed a significant effect of spinal cord stimulation compared to control for failed back syndrome (standardised mean difference [SMD; Hedges'g] −0.73; 95% CI: −1.17 to −0.30; p = 0.001) and diabetic neuropathy (SMD −1.63; 95% CI −2.06−−1.21; p < 0.001). The effect of acupuncture on chemotherapy-induced pain (SMD − 2.09; 95% CI: −4.27-0.09; p = 0.06) and electromagnetic stimulation on diabetic neuropathic pain (Hedges' g − 0.77; 95% CI: −1.82-0.27; p = 0.15) were insignificant. Conclusion: Evidence supports the use of spinal cord stimulation for the treatment of pNeP secondary to failed back surgery syndrome and diabetic neuropathy. Laser therapy was more effective than sham laser for alleviating pain due to carpal tunnel syndrome. The efficacy of acupuncture and electromagnetic therapy for chemotherapy-induced pain and diabetic neuropathy, respectively remains inconclusive.
AB - Objective: To evaluate the effectiveness of physiotherapy interventions on peripheral neuropathic pain (pNeP) due to any underlying cause. Methods: Multiple databases were searched from database inception until Dec 2021. Studies on physiotherapy interventions for pain relief assessed using the visual analogue scale among individuals with pNeP of any underlying cause were included. Methodological quality was assessed using the PEDro scale and the quality of the evidence using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. Results: The searches yielded 1498 articles. Seventeen studies met the inclusion criteria and were included in the review. Meta-analysis revealed a significant benefit for laser therapy compared to sham laser on pNeP (weighted mean difference [WMD] −1.27; 95% CI: −2.29 to −0.25; p = 0.01) in people with carpal tunnel syndrome. The pooled analyses revealed a significant effect of spinal cord stimulation compared to control for failed back syndrome (standardised mean difference [SMD; Hedges'g] −0.73; 95% CI: −1.17 to −0.30; p = 0.001) and diabetic neuropathy (SMD −1.63; 95% CI −2.06−−1.21; p < 0.001). The effect of acupuncture on chemotherapy-induced pain (SMD − 2.09; 95% CI: −4.27-0.09; p = 0.06) and electromagnetic stimulation on diabetic neuropathic pain (Hedges' g − 0.77; 95% CI: −1.82-0.27; p = 0.15) were insignificant. Conclusion: Evidence supports the use of spinal cord stimulation for the treatment of pNeP secondary to failed back surgery syndrome and diabetic neuropathy. Laser therapy was more effective than sham laser for alleviating pain due to carpal tunnel syndrome. The efficacy of acupuncture and electromagnetic therapy for chemotherapy-induced pain and diabetic neuropathy, respectively remains inconclusive.
KW - Peripheral neuropathic pain
KW - Physiotherapy
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85144277507&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2022.107055
DO - 10.1016/j.cct.2022.107055
M3 - Review article
C2 - 36535605
AN - SCOPUS:85144277507
SN - 1551-7144
VL - 125
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
M1 - 107055
ER -