Physiochemical properties and antitumor activities of two α-glucans isolated from hot water and alkaline extracts of Cordyceps (Cs-HK1) fungal mycelia

Jing Kun Yan, Wen Qiang Wang, Lin Li, Jianyong Wu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

40 Citations (Scopus)

Abstract

Two novel polysaccharides, WIPS and AIPS, were isolated and fractionated respectively from hot water and alkaline extracts of the mycelial biomass of a medicinal fungus Cordyceps sinensis (strain Cs-HK1). Through analytical and degradation experiments, WIPS and AIPS were characterized as α-d-glucans with a backbone of (1 → 4)-linked α-d-Glcp (>60%) and very similar molecular weights (Mw: WIPS 1180 kDa; AIPS 1150 kDa). WIPS had a short branch of (1 → 6)-linked α-d-Glcp (∼14%), but AIPS was a linear glucan, distinctive from the branched structures of most glucans from medicinal fungi. In aqueous alkaline solutions, both AIPS and WIPS exhibited a random coil structure with the similar conformational parameters but significantly different polydispersity indexes, 0.19 versus 0.37. AIPS exhibited much more significant antitumor and immuno-stimulatory effects than WIPS in animal tests on melanoma tumor-bearing mice.
Original languageEnglish
Pages (from-to)753-758
Number of pages6
JournalCarbohydrate Polymers
Volume85
Issue number4
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • Antitumor activity
  • Conformation
  • Medicinal fungus
  • Polysaccharides
  • Structure

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

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