Physical exercise-induced adult neurogenesis: A good strategy to prevent cognitive decline in neurodegenerative diseases?

Suk Yu Yau, Joana Gil-Mohapel, Brian R. Christie, Kwok Fai So

Research output: Journal article publicationReview articleAcademic researchpeer-review

61 Citations (Scopus)

Abstract

Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential preventative strategy/treatment to reduce cognitive decline. Here we review the functional role of adult hippocampal neurogenesis in learning and memory, and how this form of structural plasticity is altered in neurodegenerative diseases known to involve cognitive impairment. We further discuss how physical exercise may contribute to cognitive improvement in the ageing brain by preserving adult neurogenesis, and review the recent approaches for measuring changes in neurogenesis in the live human brain.
Original languageEnglish
Article number403120
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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