Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Clarence T.T. Wong; Jacky C.H. Chu; Summer Y.Y. Ha; Roy C.H. Wong; Gaole Dai; Tsz Tung Kwong; Chi Hang Wong; Dennis K.P. Ng

doi:10.1021/acs.orglett.0c02398

Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Clarence T.T. Wong (Corresponding Author)
, Jacky C.H. Chu
, Summer Y.Y. Ha
, Roy C.H. Wong
, Gaole Dai
, Tsz Tung Kwong
, Chi Hang Wong
, Dennis K.P. Ng

Research output: Journal article publication › Journal article › Academic research › peer-review

15 Citations (Scopus)

Abstract

A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

Original language	English
Pages (from-to)	7098-7102
Number of pages	5
Journal	Organic Letters
Volume	22
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.0c02398
Publication status	Published - 18 Sept 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

More information

10.1021/acs.orglett.0c02398

Cite this

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title = "Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines",

abstract = "A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy. ",

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note = "Funding Information: This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Ref. No. 14324116). Publisher Copyright: {\textcopyright} 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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doi = "10.1021/acs.orglett.0c02398",

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AU - Wong, Clarence T.T.

AU - Chu, Jacky C.H.

AU - Ha, Summer Y.Y.

AU - Wong, Roy C.H.

AU - Dai, Gaole

AU - Kwong, Tsz Tung

AU - Wong, Chi Hang

AU - Ng, Dennis K.P.

N1 - Funding Information: This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Ref. No. 14324116). Publisher Copyright: © 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/9/18

Y1 - 2020/9/18

N2 - A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

AB - A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

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M3 - Journal article

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AN - SCOPUS:85089973185

SN - 1523-7060

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JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Abstract

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