Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Clarence T.T. Wong; Jacky C.H. Chu; Summer Y.Y. Ha; Roy C.H. Wong; Gaole Dai; Tsz Tung Kwong; Chi Hang Wong; Dennis K.P. Ng

doi:10.1021/acs.orglett.0c02398

Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Clarence T.T. Wong (Corresponding Author), Jacky C.H. Chu, Summer Y.Y. Ha, Roy C.H. Wong, Gaole Dai, Tsz Tung Kwong, Chi Hang Wong, Dennis K.P. Ng

Department of Applied Biology and Chemical Technology

Research output: Journal article publication › Journal article › Academic research › peer-review

13 Citations (Scopus)

Abstract

A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

Original language	English
Pages (from-to)	7098-7102
Number of pages	5
Journal	Organic Letters
Volume	22
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.0c02398
Publication status	Published - 18 Sept 2020

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.0c02398

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title = "Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines",

abstract = "A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy. ",

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note = "Funding Information: This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Ref. No. 14324116). Publisher Copyright: {\textcopyright} 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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AU - Wong, Clarence T.T.

AU - Chu, Jacky C.H.

AU - Ha, Summer Y.Y.

AU - Wong, Roy C.H.

AU - Dai, Gaole

AU - Kwong, Tsz Tung

AU - Wong, Chi Hang

AU - Ng, Dennis K.P.

N1 - Funding Information: This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Ref. No. 14324116). Publisher Copyright: © 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/9/18

Y1 - 2020/9/18

N2 - A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

AB - A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

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M3 - Journal article

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JO - Organic Letters

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ER -

Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Abstract

ASJC Scopus subject areas

UN SDGs

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