Phthalaldehyde-Amine Capture Reactions for Bioconjugation and Immobilization of Phthalocyanines

Clarence T.T. Wong (Corresponding Author), Jacky C.H. Chu, Summer Y.Y. Ha, Roy C.H. Wong, Gaole Dai, Tsz Tung Kwong, Chi Hang Wong, Dennis K.P. Ng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, and be immobilized on the surface of bovine serum album nanoparticles and glass slides using the versatile and efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects of the latter two materials have also been examined against cancer cells and bacteria, respectively, showing that they are highly efficient photosensitizing systems for photodynamic therapy.

Original languageEnglish
Pages (from-to)7098-7102
Number of pages5
JournalOrganic Letters
Volume22
Issue number18
DOIs
Publication statusPublished - 18 Sep 2020
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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