In the present study, the degradation of the iodinated X-ray contract medium (ICM) iopromide in aqueous solution by the combined oxidants of S2O82" and H2O2 with UV irradiation has been investigated. All experiments were carried out on a laboratory scale set-up. The effects of various parameters including different wavelengths of UV irradiation, numbers of UV lamps, and initial solution pH on the degradation efficiency have been evaluated. In addition, the presence of certain organic matters such as glucose and humic acid on the influence of the process performance was also assessed. Experimental results show that the wavelength of 254 nm exhibits best decay of ICM among the three tested wavelengths (254, 300 and 350 nm). ICM photo-decay rate linearly increases with the number of UV lamps. For the effect of solution pH, optimum performance was observed to be pH=4.34. Additionally, the sequential addition of S2O82- and H2O2 was also studied and the degradation efficiency was ranked in the following order: UV/S2O82-7H2O2>UV/H2O2+S2O82-> UV/S2O82-+H2O2. Furthermore, test results indicate that ICM photodecay rate by UV/S2O82-7H2O2 process is significantly inhibited in the presence of glucose or/and humic acid, suggesting certain pre-treatment measures should be taken to abate their negative effect upon real application.