Photodegradable and pH responsive nanocapsules encapsulated with upconversion nanoparticles for diagnosis and treatment

Xiaotao Wang, Wei Hu, Yebin Yang, Yonggui Liao, Wing Cheung Law, Chak Yin Tang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

Multifunctional composite nanoparticles with monodispersity and uniform particle size can be synthesized by distillation precipitation polymerization. The rare-earth upconversion nanoparticles were used as the core–shell structure and emit visible light under 980 nm near-infrared light for developing imaging. A layer of template SiO2 was coated by reverse microemulsion method, and the surface of SiO2 was coated with reactive polymer (ONB/PMAA) by distillation precipitation polymerization. The composite nanoparticles with a certain hollow structure were formed under after etch of HF. DOX was loaded into the particles, the drug loading rate was 6.23 %. Under acidic conditions, the PMAA layer shrinked and released the drug. Under the stimulation of UV light, the ONB (5-methylallyloxy-2-nitrobenzyl methacrylate) will photocleavage and release the internal drug. Under the stimulation of pH = 4 and UV light, the release rate could reach up to 85.13 %. Human breast cancer cells (MCF-7) were used as experimental subjects to investigate the drug release behavior in living cells by cytotoxicity assay and cellular uptake. The composite nanoparticles were found to have lower cytotoxicity and stable drug release behavior.

Original languageEnglish
Article number111715
Number of pages10
JournalEuropean Polymer Journal
Volume182
DOIs
Publication statusPublished - 3 Jan 2023

Keywords

  • Controlled drug release
  • Nanocomposite
  • Photo-degradation
  • Upconversion nanoparticle

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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