@article{1f085332516f4b7bab49bd837695583c,
title = "Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy",
abstract = "Therapeutic effects of photodynamic therapy (PDT)remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs)for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP)are prepared by coating Prussian blue (PB)with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP)NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy.",
keywords = "Biological Sciences, Catalysis, Chemistry, Drug Delivery System, Inorganic Chemistry",
author = "Dongdong Wang and Ruohong Shi and Jiajia Zhou and Sixiang Shi and Huihui Wu and Pengping Xu and Hui Wang and Guoliang Xia and Barnhart, {Todd E.} and Weibo Cai and Zhen Guo and Qianwang Chen",
note = "Funding Information: This work was supported by the MOST Grant 2016YFA0101202 ; The National Natural Science Foundation of China , 21571168 , 31471268 , and U1232211 ; National Key R&D Program of China 2016YFA0401801 ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ( 2016FXCX005 ); CAS/SAFEA International Partnership Program for Creative Research Teams and CAS Hefei Science Center ( 2016HSC-IU011 ); the NIH ( P30CA014520 ); and the American Cancer Society ( 125246-RSG-13-099-01-CCE ). The authors are also thankful for the support of the Core Facility Center for Life Sciences of University of Science and Technology of China for imaging support. Funding Information: This work was supported by the MOST Grant 2016YFA0101202; The National Natural Science Foundation of China, 21571168, 31471268, and U1232211; National Key R&D Program of China 2016YFA0401801; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology (2016FXCX005); CAS/SAFEA International Partnership Program for Creative Research Teams and CAS Hefei Science Center (2016HSC-IU011); the NIH (P30CA014520); and the American Cancer Society (125246-RSG-13-099-01-CCE). The authors are also thankful for the support of the Core Facility Center for Life Sciences of University of Science and Technology of China for imaging support. Conceptualization, Q.C. W.C. and Z.G.; Methodology, D.W. R.S. H.Wang and G.X.; Investigation, D.W. R.S. and P.X.; Experiments, D.W. R.S. J.Z. S.S. and H.Wu; Writing – Original Draft, D.W. and R.S.; Writing – Review & Editing, D.W. and H.Wang; Funding Acquisition, Q.C. Z.G. and W.C.; Resources, Q.C. W.C. Z.G. and T.E.B.; Supervision, Q.C. Z.G. and W.C.; D.W. R.S. and J.Z. conducted the project and contributed equally. Dedicated to University of Science and Technology of China (USTC)on the occasion of its 60th anniversary. The authors declare no competing interest. Publisher Copyright: {\textcopyright} 2018 The Authors Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2018",
month = nov,
day = "30",
doi = "10.1016/j.isci.2018.10.005",
language = "English",
volume = "9",
pages = "14--26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
}