Phloridzin improves lipoprotein lipase activity in stress-loaded mice via AMPK phosphorylation

Guo En Wang, Yi Fang Li, Yan Ping Wu, Bun Tsoi, Shi Jie Zhang, Ling Fang Cao, Hiroshi Kurihara, Rong Rong He

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)


Long-term stress exposure can lead to disturbed homeostasis and cause many life-style diseases. Phloridzin possesses various bioactivities, but the understanding of the effects of phloridzin on stress-related lipid metabolism disorder is limited. Our results demonstrate that phloridzin improved plasma lipoprotein lipase (LPL) activity and triglyceride metabolism in restrained mice. A decrease of angiopoietin-like protein 4 (ANGPTL4) mRNA expression and an increase of AMP-Activated protein kinase (AMPK) phosphorylation were observed after phloridzin treatment. After inhibiting AMPK phosphorylation, the effects of phloridzin on the amelioration of plasma LPL activity and suppression of ANGPTL4 expression were blocked. In addition, cardiac AMPK phosphorylation, plasma LPL activity and ANGPTL4 expression were also affected by phloridzin, even if the glucocorticoid receptor was blocked. Taken together, the down-regulation of ANGPTL4 expression by phloridzin was probably via a direct activation of AMPK pathway. This discovery can provide a biochemical and nutritional basis for the use of phloridzin-containing food and beverage in daily life.

Original languageEnglish
Pages (from-to)874-880
Number of pages7
JournalInternational Journal of Food Sciences and Nutrition
Issue number7
Publication statusPublished - 1 Nov 2014
Externally publishedYes


  • Angiopoietin-like protein 4
  • Apple polyphenol extract
  • Glucocorticoids
  • Lipid metabolism
  • Restraint stress

ASJC Scopus subject areas

  • Food Science


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