Phase correction for three-dimensional (3D) diffusion-weighted interleaved EPI using 3D multiplexed sensitivity encoding and reconstruction (3D-MUSER)

Hing Chiu Chang (Corresponding Author), Edward S. Hui, Pui Wai Chiu, Xiaoxi Liu, Nan Kuei Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)


Purpose: Three-dimensional (3D) multiplexed sensitivity encoding and reconstruction (3D-MUSER) algorithm is proposed to reduce aliasing artifacts and signal corruption caused by inter-shot 3D phase variations in 3D diffusion-weighted echo planar imaging (DW-EPI). Theory and Methods: 3D-MUSER extends the original framework of multiplexed sensitivity encoding (MUSE) to a hybrid k-space-based reconstruction, thereby enabling the correction of inter-shot 3D phase variations. A 3D single-shot EPI navigator echo was used to measure inter-shot 3D phase variations. The performance of 3D-MUSER was evaluated by analyses of point-spread function (PSF), signal-to-noise ratio (SNR), and artifact levels. The efficacy of phase correction using 3D-MUSER for different slab thicknesses and b-values were investigated. Results: Simulations showed that 3D-MUSER could eliminate artifacts because of through-slab phase variation and reduce noise amplification because of SENSE reconstruction. All aliasing artifacts and signal corruption in 3D interleaved DW-EPI acquired with different slab thicknesses and b-values were reduced by our new algorithm. A near-whole brain single-slab 3D DTI with 1.3-mm isotropic voxel acquired at 1.5T was successfully demonstrated. Conclusion: 3D phase correction for 3D interleaved DW-EPI data is made possible by 3D-MUSER, thereby improving feasible slab thickness and maximum feasible b-value. Magn Reson Med 79:2702–2712, 2018.

Original languageEnglish
Pages (from-to)2702-2712
Number of pages11
JournalMagnetic Resonance in Medicine
Issue number5
Publication statusPublished - May 2018
Externally publishedYes


  • 3D diffusion-weighted imaging
  • 3D interleaved EPI
  • 3D phase correction
  • multiplexed sensitivity encoding

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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