Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb

Xi Can Tang, Yifan Han

Research output: Journal article publicationReview articleAcademic researchpeer-review

102 Citations (Scopus)

Abstract

HupA, a novel alkaloid isolated from the Chinese medicinal herb Huperzia serrata, is a reversible, potent, and selective inhibitor of AChE. Compared with other well-known AChEIs, such as physostigmine, galanthamine, tacrine, and even donepezil, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. HupA exhibited memory-enhancing efficacy in a broad range of animal models of cognitive impairment. Double-blind and placebo-controlled clinical trials have demonstrated that HupA produced significant improvements in memory deficiencies in aged patients and patients with AD. Furthermore, both animal and clinical safety testings showed that HupA was devoid of unexpected toxicity, particularly the dose-limiting hepatotoxicity induced by tacrine. These encouraging preclinical and clinical findings suggest that HupA is a highly promising candidate for clinical development as a symptomatic treatment for AD and other memory disorders related to a central cholinergic deficiency.
Original languageEnglish
Pages (from-to)281-300
Number of pages20
JournalCNS Drug Reviews
Volume5
Issue number3
Publication statusPublished - 1 Sep 1999
Externally publishedYes

Keywords

  • Acetylcholinesterase
  • Alzheimer's disease
  • Cholinesterase inhibitor
  • Cognition enhancer
  • Donepezil
  • Galanthamine
  • Huperzine A
  • NMDA receptor
  • Physostigmine
  • Tacrine

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Pharmacology

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