PH-triggered poly(ethylene glycol)-poly(lactic acid/glycolic acid)/ croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy

Shiying Li; Kwok Ho Lui; Xin Li; Xueyang Fang; Wai Sum Lo; Yan Juan Gu; Wing Tak Wong

doi:10.1021/acsabm.0c01578

PH-triggered poly(ethylene glycol)-poly(lactic acid/glycolic acid)/ croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy

Shiying Li, Kwok Ho Lui, Xin Li, Xueyang Fang, Wai Sum Lo, Yan Juan Gu (Corresponding Author), Wing Tak Wong (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

19 Citations (Scopus)

Abstract

The most advantageous and attractive property of photoacoustic imaging is its capability to visualize and differentiate multiple species according to their unique absorbance profiles simultaneously in a single mixture. We here report the pH-sensitive near-infrared (NIR) croconaine (Croc) dyes-loaded copolymeric PEG-PLGA nanoparticles (NPs) for in vivo multiplexed PA imaging and pH-responsive photothermal therapy (PTT) in an orthotopic xenograft model. PEG chains on the polymeric NPs shell were conjugated with iRGD in another set of NPs to realize efficient tumor targeting. The distribution and the intensity of two sets of iRGD-targeted and nontargeted NPs inside tumors are simultaneously imaged and monitored in vivo. Meanwhile, the utilization of iRGD-targeted PPC815 NPs as a pH-active photothermal agent with promising tumor-inhibition efficacy was demonstrated. As a result, this nanoplatform is capable of assisting multiwavelength unmixing of PA imaging as well as providing remarkable photothermal ablation for anticancer treatment.

Original language	English
Pages (from-to)	4152-4164
Number of pages	13
Journal	ACS Applied Bio Materials
Volume	4
Issue number	5
DOIs	https://doi.org/10.1021/acsabm.0c01578
Publication status	Published - 17 May 2021

Keywords

PEG-PLGA nanoparticles
multiplexed photoacoustic imaging
orthotopic xenograft model
photothermal therapy
spectra unmixing

ASJC Scopus subject areas

General Chemistry
Biomaterials
Biomedical Engineering
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1021/acsabm.0c01578

http://hdl.handle.net/10397/91656

Cite this

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title = "PH-triggered poly(ethylene glycol)-poly(lactic acid/glycolic acid)/ croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy",

abstract = "The most advantageous and attractive property of photoacoustic imaging is its capability to visualize and differentiate multiple species according to their unique absorbance profiles simultaneously in a single mixture. We here report the pH-sensitive near-infrared (NIR) croconaine (Croc) dyes-loaded copolymeric PEG-PLGA nanoparticles (NPs) for in vivo multiplexed PA imaging and pH-responsive photothermal therapy (PTT) in an orthotopic xenograft model. PEG chains on the polymeric NPs shell were conjugated with iRGD in another set of NPs to realize efficient tumor targeting. The distribution and the intensity of two sets of iRGD-targeted and nontargeted NPs inside tumors are simultaneously imaged and monitored in vivo. Meanwhile, the utilization of iRGD-targeted PPC815 NPs as a pH-active photothermal agent with promising tumor-inhibition efficacy was demonstrated. As a result, this nanoplatform is capable of assisting multiwavelength unmixing of PA imaging as well as providing remarkable photothermal ablation for anticancer treatment.",

keywords = "PEG-PLGA nanoparticles, multiplexed photoacoustic imaging, orthotopic xenograft model, photothermal therapy, spectra unmixing",

author = "Shiying Li and Lui, {Kwok Ho} and Xin Li and Xueyang Fang and Lo, {Wai Sum} and Gu, {Yan Juan} and Wong, {Wing Tak}",

note = "Funding Information: This work was financially supported by the Area of Excellence Grants (1-ZVGG) from Hong Kong Polytechnic University, the National Natural Science Foundation of China (32071376), and the Collaborative Research Fund Equipment Grant (C5012-15E) from the Research Grants Council, HKSAR Government. Publisher Copyright: {\textcopyright} 2021 The Authors. Published by American Chemical Society.",

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language = "English",

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PH-triggered poly(ethylene glycol)-poly(lactic acid/glycolic acid)/ croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy. / Li, Shiying; Lui, Kwok Ho; Li, Xin et al.
In: ACS Applied Bio Materials, Vol. 4, No. 5, 17.05.2021, p. 4152-4164.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - PH-triggered poly(ethylene glycol)-poly(lactic acid/glycolic acid)/ croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy

AU - Li, Shiying

AU - Lui, Kwok Ho

AU - Li, Xin

AU - Fang, Xueyang

AU - Lo, Wai Sum

AU - Gu, Yan Juan

AU - Wong, Wing Tak

N1 - Funding Information: This work was financially supported by the Area of Excellence Grants (1-ZVGG) from Hong Kong Polytechnic University, the National Natural Science Foundation of China (32071376), and the Collaborative Research Fund Equipment Grant (C5012-15E) from the Research Grants Council, HKSAR Government. Publisher Copyright: © 2021 The Authors. Published by American Chemical Society.

PY - 2021/5/17

Y1 - 2021/5/17

N2 - The most advantageous and attractive property of photoacoustic imaging is its capability to visualize and differentiate multiple species according to their unique absorbance profiles simultaneously in a single mixture. We here report the pH-sensitive near-infrared (NIR) croconaine (Croc) dyes-loaded copolymeric PEG-PLGA nanoparticles (NPs) for in vivo multiplexed PA imaging and pH-responsive photothermal therapy (PTT) in an orthotopic xenograft model. PEG chains on the polymeric NPs shell were conjugated with iRGD in another set of NPs to realize efficient tumor targeting. The distribution and the intensity of two sets of iRGD-targeted and nontargeted NPs inside tumors are simultaneously imaged and monitored in vivo. Meanwhile, the utilization of iRGD-targeted PPC815 NPs as a pH-active photothermal agent with promising tumor-inhibition efficacy was demonstrated. As a result, this nanoplatform is capable of assisting multiwavelength unmixing of PA imaging as well as providing remarkable photothermal ablation for anticancer treatment.

AB - The most advantageous and attractive property of photoacoustic imaging is its capability to visualize and differentiate multiple species according to their unique absorbance profiles simultaneously in a single mixture. We here report the pH-sensitive near-infrared (NIR) croconaine (Croc) dyes-loaded copolymeric PEG-PLGA nanoparticles (NPs) for in vivo multiplexed PA imaging and pH-responsive photothermal therapy (PTT) in an orthotopic xenograft model. PEG chains on the polymeric NPs shell were conjugated with iRGD in another set of NPs to realize efficient tumor targeting. The distribution and the intensity of two sets of iRGD-targeted and nontargeted NPs inside tumors are simultaneously imaged and monitored in vivo. Meanwhile, the utilization of iRGD-targeted PPC815 NPs as a pH-active photothermal agent with promising tumor-inhibition efficacy was demonstrated. As a result, this nanoplatform is capable of assisting multiwavelength unmixing of PA imaging as well as providing remarkable photothermal ablation for anticancer treatment.

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KW - orthotopic xenograft model

KW - photothermal therapy

KW - spectra unmixing

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PH-triggered poly(ethylene glycol)-poly(lactic acid/glycolic acid)/ croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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