Abstract
Exogenous prostaglandin E2 (PGE2) displays mixed regulatory properties with regard to inflammatory gene expression in dorsal root ganglion (DRG) cells. We show here that endogenously-produced nanomolar concentrations of PGE2, such as that generated in response to Toll-like receptor 4 (TLR4) stimulation, inhibits both cyclooxygenase-2 (COX-2) and tumour necrosis factor alpha (TNFα) mRNA expression in DRG cells in an EP4 receptor-dependent manner. DRG neurons appear to be the major source of PGE2 in the DRG and likely serve as both an autocrine and paracrine system for limiting over-activation of both DRG neurons and glial cells in response to TLR4 stimulation.
Original language | English |
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Pages (from-to) | 8-16 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 293 |
Early online date | 10 Feb 2016 |
DOIs | |
Publication status | Published - 15 Apr 2016 |
Externally published | Yes |
Keywords
- Dorsal root ganglia
- EP
- PGE
- Primary sensory neurons
- Toll-like receptor 4
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology