Personal exposure to fine particles (PM2.5) and respiratory inflammation of common residents in Hong Kong

Zhanlan Fan, Vivian C. Pun, Xiao Cui Chen, Qiu Hong, Linwei Tian, Steven Sai Hang Ho, Shuncheng Lee, Lap Ah Tse, Kin Fai Ho

Research output: Journal article publicationJournal articleAcademic researchpeer-review

26 Citations (Scopus)

Abstract

Background: Given the lack of research on the personal exposure to fine particles (PM2.5) in Hong Kong, we examined the association between short-term personal exposure to PM2.5and their constituents and inflammation in exhaled breath in a sample of healthy adult residents. Method: Forty-six participants underwent personal PM2.5monitoring for averagely 6 days to obtain 276 samples. Fractional exhaled nitric oxide (FeNO), a biomarker of inflammation in exhaled breath, was measured at the end of each 24-h personal monitoring. PM2.5chemical constituents, including organic carbon, elemental carbon, 16 polycyclic aromatic hydrocarbons (PAHs), and 6 phthalate esters, were speciated from the personal samples collected. A mixed-effects model was used to estimate the association of PM2.5and their constituents with FeNO. The comparison was also made with parallel analyses using ambient concentrations. Results: Personal exposures to PM2.5(28.1 ± 23.3 μg/m3) were higher than the ambient levels (13.3 ± 6.4 μg/m3) monitored by stations. The composition profile and personal-to-ambient concentration ratio varied among subjects with different occupations. An interquartile range (IQR) change in personal exposure to PM2.5was positively associated with 12.8% increase in FeNO (95% confidence interval, CI: 5.5–20.7%), while nil association was found for ambient PM2.5. Among the constituents measured, only the carcinogenic PAHs were significantly associated with 12% increase in FeNO responses (95% CI, 0.0–25.6%). Conclusion: In conclusion, our study provides the first understanding about personal exposure to PM2.5and possible sources in Hong Kong. The results also showed that personal exposure to PM2.5and c-PAHs were linked to increased FeNO levels among healthy adults.
Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalEnvironmental Research
Volume164
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Carbonaceous materials
  • Fine particles
  • Personal exposure
  • Polycyclic aromatic hydrocarbons
  • Respiratory inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this