Periodic pressure pulse generator in cell culture chip

Y. F. Yu, X. Zhang, R. Chua, P. H. Yap, A. Q. Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

For studying the effect of stress on cell growth, this paper presents a design of cell culture chip, which can generate periodic pressure pulses via fluidic control system and generate pressure pulses with different amplitudes via hydrodynamic pressure. Pressure pulses ranging from 180 mmHg to 80 mmHg are obtained. This chip features wide frequency range (from 0 to 100 pulses/min), tunable duty cycle (from 0 to 1) and no shear stress effect, making the cell culture chip promising for many applications, for example, biological research on the relation between hypertension and cancer.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages188-190
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - Oct 2007
Externally publishedYes
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 7 Oct 200711 Oct 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period7/10/0711/10/07

Keywords

  • Cell culture
  • Microfluidic chip
  • Pressure pulse
  • Stress

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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