Pd-catalyzed cross-coupling of highly sterically congested enol carbamates with grignard reagents via c-o bond activation

Zicong Chen, Chau Ming So

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)


The palladium-catalyzed cross-coupling reaction of enol carbamates to construct highly sterically congested alkenyl compounds is presented for the first time. This protocol demonstrates the potential of using thermally stable and highly atom-economic enol electrophiles as building blocks in bulky alkene synthesis. This reaction accommodates a broad substrate scope with excellent Z/E isomer ratios, which also provides a new synthetic pathway for accessing Tamoxifen.

Original languageEnglish
Pages (from-to)3879-3883
Number of pages5
JournalOrganic Letters
Issue number10
Publication statusPublished - 15 May 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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