Pathogenic Virus Detection by Optical Nanobiosensors

Menglin Song, Mo Yang, Jianhua Hao

Research output: Journal article publicationReview articleAcademic researchpeer-review

31 Citations (Scopus)


The novel coronavirus pandemic is sweeping the world and causing global crises. The lack of effective methods of early diagnosis and accurate detection may result in severe infection as well as mortality. Therefore, it is urgently required that rapid, selective, and accurate techniques for detecting pathogenic viruses are developed. Nanotechnology-based biosensors are finding many applications in biological detection, which may address these issues and realize direct detection of molecular targets in real time. Among various nanoplatforms, optical nanobiosensors have aroused much interest due to their inherent advantages of high sensitivity and direct readout. In this review, a summary of recent progress on the optical biosensors based on nanotechnology for pathogenic virus detection is provided, with focus on quantum dots (QDs), upconversion nanoparticles (UCNPs), noble metal nanoparticles, and organic fluorescent molecules-based nanoprobes and chemiluminescence assays. These representative studies demonstrate appealing performance as biosensors and hold great promise for clinical diagnosis.

Original languageEnglish
Article number100288
JournalCell Reports Physical Science
Issue number1
Publication statusPublished - 20 Jan 2021


  • nanobiosensor
  • optical
  • pathogenic viruses detection

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Materials Science
  • General Chemistry
  • General Energy
  • General Engineering


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