Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation

Ming chao He, Zhe Shi, Nan nan Sha, Nan Chen, Shi yu Peng, Duan fang Liao, Man sau Wong, Xiao li Dong, Yong jun Wang, Ti fei Yuan, Yan Zhang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)

Abstract

Depression is highly prevalent in patients suffering from chronic inflammatory diseases. Dysregulated neuroinflammation and concomitant activated microglia play a pivotal role in the pathogenesis of depression. Paricalcitol (Pari), a vitamin D2 analogue, has been demonstrated to exert anti-inflammative effects on renal and cardiovascular diseases. In this study, mice were pretreated with Pari before being induced to acute depression-like behaviors by systemic lipopolysaccharide (LPS) injection. To determine the therapeutic effects of Pari, alterations in acute body weight, sucrose preference, forced swimming and tail suspension tests were assessed. Then, alterations of pro-inflammation cytokine IL1-β level and microglia activity in the hypothalamus, which are involved in the pathophysiology of depression, were examined. The results showed that Pari significantly alleviated systemic LPS injection induced depressive-like behaviors as shown by increased sucrose preference and decreased TST and FST immobility. Pari could specifically regulate microglia-mediated neuroinflammation process and local activity of renin-angiotensin system to exert its anti-depressant effects. This study demonstrated a potential for paricalcitol in treating depressive symptoms induced by systemic inflammation, particularly in patients with chronic hypertension.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiochemical Pharmacology
Volume163
DOIs
Publication statusPublished - May 2019

Keywords

  • Depression-like behavior
  • LPS
  • Microgliosis
  • Neuroinflammation
  • Paricalcitol

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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