Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk

L. Baum, H.K. Ng, K.S. Woo, B. Tomlinson, T.H. Rainer, Xiangyan Chen, W.S. Cheung, D.K. Yin Chan, G.N. Thomas, C.S. Wai Tong, K.S. Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

46 Citations (Scopus)

Abstract

Objectives: Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease. Design and methods: In a case control study, we genotyped 242 ischemic stroke, 231 myocardial infarction (MI), and 310 healthy control subjects, all Chinese. Results: R-containing genotypes (R+) were associated with vascular disease, OR = 1.5, P = 0.03. RR was increased in MI patients who were either smokers (OR = 3.1, P = 0.01), male, or younger than 60. R+ but not RR genotypes were increased in stroke patients, particularly large artery type (OR = 2.6 and P = 0.02 for R+, OR =1.0 for RR) or among smokers. The relative dearth of RR in stroke might be due to earlier MI or death in at-risk people, such as smokers. R+ genotypes were increased with stroke in hypertensive (OR = 2.1, P = 0.02) but not normotensive (OR = 1.0) subjects. Conclusions: PON1 192R+ genotypes were associated with stroke and MI, particularly in subsets of patients, in patterns suggesting a possible survivor effect. © 2006 The Canadian Society of Clinical Chemists. All rights reserved.
Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalClinical Biochemistry
Volume39
Issue number3
DOIs
Publication statusPublished - 1 Jan 2006
Externally publishedYes

Keywords

  • Ischemic stroke
  • Myocardial infarction
  • Paraoxonase
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Biochemistry

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