PAMI: A Computational Module for Joint Estimation and Progression Prediction of Glaucoma

Linchuan Xu, Ryo Asaoka, Taichi Kiwaki, Hiroshi Murata, Yuri Fujino, Kenji Yamanishi

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Glaucoma, which can cause irreversible damage to the sight of human eyes, is conventionally diagnosed by visual field (VF) sensitivity. However, it is labor-intensive and time-consuming to measure VF. Recently, optical coherence tomography (OCT) has been adopted to measure retinal layers thickness (RT) for assisting the diagnosis because glaucoma makes structural changes to RT and it is much less costly to obtain RT. In particular, RT can assist in mainly two manners. One is to estimate a VF from an RT such that clinical doctors only need to obtain an RT of a patient and then convert it to a VF for the diagnosis. The other is to predict future VFs by utilizing both past VFs and RTs, i.e., the prediction of progression of VF over time. The two computational tasks are performed as two data mining tasks because currently there is no knowledge about the exact form of the computations involved. In this paper, we study a novel problem which is the integration of the two data mining tasks. The motivation is that both the two data mining tasks deal with transforming information from the RT domain to the VF domain such that the knowledge discovered in one task can be useful for another. The integration is non-trivial because the two tasks do not share the way of transformation. To address this issue, we design a progression-agnostic and mode-independent (PAMI) module which facilitates cross-task knowledge utilization. We empirically demonstrate that our proposed method outperforms the state-of-the-art method for the estimation by 6.33% in terms of mean of the root mean square error on a real dataset, and outperforms the state-of-the-art method for the progression prediction by 3.49% for the best case.

Original languageEnglish
Title of host publicationKDD 2021 - Proceedings of the 27th ACM SIGKDD Conference on Knowledge Discovery and Data Mining
PublisherAssociation for Computing Machinery
Pages3826-3834
Number of pages9
ISBN (Electronic)9781450383325
DOIs
Publication statusPublished - 14 Aug 2021
Event27th ACM SIGKDD Conference on Knowledge Discovery and Data Mining, KDD 2021 - Virtual, Online, Singapore
Duration: 14 Aug 202118 Aug 2021

Publication series

NameProceedings of the ACM SIGKDD International Conference on Knowledge Discovery and Data Mining

Conference

Conference27th ACM SIGKDD Conference on Knowledge Discovery and Data Mining, KDD 2021
Country/TerritorySingapore
CityVirtual, Online
Period14/08/2118/08/21

Keywords

  • convolutional neural networks
  • glaucoma prediction
  • matrix factorization
  • multi-task learning
  • multi-view learning
  • regression

ASJC Scopus subject areas

  • Software
  • Information Systems

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