Palladium-(S,pR)-FerroNPS-catalyzed asymmetric allylic etherification: Electronic effect of nonconjugated substituents on benzylic alcohols on enantioselectivity

Fuk Loi Lam, Terry Tin Lok Au-Yeung, Fuk Yee Kwong, Zhongyuan Zhou, Kwok Yin Wong, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

78 Citations (Scopus)

Abstract

(Chemical Equation Presented) An enantioselective C-O bond-forming reaction proceeds well under palladium catalysis with newly developed N-P,S ligands with a ferrocene motif (see scheme). Nonconjugated substituents on the benzylic alcohol substrate lead to an increase in enantioselectivity with increasing electron-donating ability in the title reaction with racemic 1,3-diphenyl-2-propenyl acetate. Cy = cyclohexyl. KGaA.
Original languageEnglish
Pages (from-to)1280-1283
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number7
DOIs
Publication statusPublished - 1 Feb 2008

Keywords

  • Asymmetric catalysis
  • Electronic effects
  • Etherification
  • P,S ligands
  • Palladium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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