Abstract
Palladium-catalyzed direct arylation of α,β-unsaturated carbonyl compounds is an efficient and attractive strategy to access arylated α,β-unsaturated carbonyl compounds through the construction of carbon carbon bonds. This reaction has several challenges, especially in terms of the control of regioselectivity between α- and γ-arylation and the selectivity for monoarylation and multiple arylation. Herein, we discuss the recent development of γ-arylation of α,β-unsaturated carbonyl compounds and present the ligand-controlled, site-selective α- and γ-arylation of α,β-unsaturated carbonyl ketones with (hetero)aryl halides. The site selectivity of the reaction is switchable by simply changing the phosphine ligand. 1 Introduction 2 Reaction Development and Mechanistic Investigation 3 Conclusion and Outlook.
Original language | English |
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Pages (from-to) | 805-814 |
Number of pages | 10 |
Journal | Synlett |
Volume | 33 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Jun 2022 |
Keywords
- arylation
- palladium catalysis
- phosphine ligand
- regioselectivity
- α,β-unsaturated ketones
ASJC Scopus subject areas
- Organic Chemistry