Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates

Wai Chung Fu, Chau Ming So, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

78 Citations (Scopus)

Abstract

The first general palladium catalyst for the phosphorylation of aryl mesylates and tosylates is reported. The newly developed system exhibits excellent functional group compatibility. For instance, free amino, keto, ester, and amido groups, as well as heterocycles, remain intact during the course of reaction. The mesylated derivatives of biologically active compounds such as 17β-estradiol and 6-hydroxyflavone are also shown to be applicable substrates. A one-pot phosphorylation-amination sequence is described for the facile synthesis of potential pharmacophores.
Original languageEnglish
Pages (from-to)5906-5909
Number of pages4
JournalOrganic Letters
Volume17
Issue number23
DOIs
Publication statusPublished - 17 Nov 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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