Abstract
Palladium-catalyzed C-N bond coupling reaction between NH-sulfoximines and aryl halides (e.g., -Br, -I, and -Cl and pseudohalides -OTf and -ONf) was successfully achieved. Nevertheless, aryl tosylates/mesylates left much to be achieved. In this report, a general N-arylation of sulfoximines with aryl sulfonates is described. Using Pd(OAc) 2 /MeO-CM-phos complex, the N-aryl sulfoximine products can be obtained in good-to-excellent yields (up to 99%) with good common functional group compatibility. In addition to arene moieties, alkenyl tosylates are shown to be successful coupling partners.
Original language | English |
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Pages (from-to) | 11369-11376 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 18 |
DOIs | |
Publication status | Published - 21 Sept 2018 |
ASJC Scopus subject areas
- Organic Chemistry