Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

Dong Sheng Lee; Pui Ying Choy; Chau Ming So; Jun Wang; Chak Po Lau; Fuk Yee Kwong

doi:10.1039/c2ra21667a

Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

Dong Sheng Lee, Pui Ying Choy, Chau Ming So, Jun Wang, Chak Po Lau, Fuk Yee Kwong

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

37 Citations (Scopus)

Abstract

This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.

Original language	English
Pages (from-to)	9179-9182
Number of pages	4
Journal	RSC Advances
Volume	2
Issue number	24
DOIs	https://doi.org/10.1039/c2ra21667a
Publication status	Published - 19 Dec 2012

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c2ra21667a

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abstract = "This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.",

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AU - Choy, Pui Ying

AU - So, Chau Ming

AU - Wang, Jun

AU - Lau, Chak Po

AU - Kwong, Fuk Yee

PY - 2012/12/19

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AB - This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.

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JF - RSC Advances

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ER -

Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

Abstract

ASJC Scopus subject areas

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