Abstract
In this study, a novel and efficient Pd-catalyzed chemoselective deuterodehalogenation reaction of halogenated aryl triflates was developed using isopropanol-d8 as the deuterium source. This chemoselective reaction afforded an unconventional chemoselectivity order of C−Br > C−Cl > C−OTf. This catalytic system was successfully applied to chemoselective hydrodehalogenation of chloroaryl triflates, providing excellent C−Cl chemoselectivity over C−OTf.
Original language | English |
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Pages (from-to) | 8429-8433 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 25 |
Issue number | 47 |
DOIs | |
Publication status | Published - 17 Nov 2023 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry