Palladium-Catalyzed Deuterodehalogenation of Halogenated Aryl Triflates Using Isopropanol‑d8 as the Deuterium Source

Miao Wang, Wai Hang Pang, On Ying Yuen, Shan Shan Ng, Chau Ming So

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

In this study, a novel and efficient Pd-catalyzed chemoselective deuterodehalogenation reaction of halogenated aryl triflates was developed using isopropanol-d8 as the deuterium source. This chemoselective reaction afforded an unconventional chemoselectivity order of C−Br > C−Cl > C−OTf. This catalytic system was successfully applied to chemoselective hydrodehalogenation of chloroaryl triflates, providing excellent C−Cl chemoselectivity over C−OTf.

Original languageEnglish
Pages (from-to)8429-8433
Number of pages5
JournalOrganic Letters
Volume25
Issue number47
DOIs
Publication statusPublished - 17 Nov 2023

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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