Palladium-catalyzed decarboxylative arylation of C-H bonds by aryl acylperoxides

Wing Yiu Yu, Wing Nga Sit, Zhongyuan Zhou, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

163 Citations (Scopus)

Abstract

A Pd(OAc)2-catalyzed protocol for decarboxylative arylation of aromatic C-H bond was developed using aryl acylperoxides as inexpensive aryl sources. Substrates containing pyridyl, oxime, and oxazoline groups undergo effectively ortho-selective C-H arylation with excellent functional group tolerance. This arylation should begin by directing-group-assisted cyclopalladation, followed by the reaction of the palladacycle with aryl radicals generated in situ by thermal decomposition of the peroxides.
Original languageEnglish
Pages (from-to)3174-3177
Number of pages4
JournalOrganic Letters
Volume11
Issue number15
DOIs
Publication statusPublished - 6 Aug 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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