TY - JOUR
T1 - Palladium-Catalyzed C(sp 2 )-N Bond Cross-Coupling with Triaryl Phosphates
AU - Chen, Zicong
AU - Chen, Xiangmeng
AU - So, Chau Ming
PY - 2019/5/17
Y1 - 2019/5/17
N2 - The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(?-cinnamyl)Cl] 2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.
AB - The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(?-cinnamyl)Cl] 2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.
UR - http://www.scopus.com/inward/record.url?scp=85065787153&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.9b00703
DO - 10.1021/acs.joc.9b00703
M3 - Journal article
C2 - 31038958
AN - SCOPUS:85065787153
SN - 0022-3263
VL - 84
SP - 6366
EP - 6376
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 10
ER -