Palladium-Catalyzed C(sp 2 )-N Bond Cross-Coupling with Triaryl Phosphates

Zicong Chen, Xiangmeng Chen, Chau Ming So

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)


The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(?-cinnamyl)Cl] 2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Original languageEnglish
Pages (from-to)6366-6376
Number of pages11
JournalJournal of Organic Chemistry
Issue number10
Publication statusPublished - 17 May 2019

ASJC Scopus subject areas

  • Organic Chemistry


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