Abstract
The first palladium-catalyzed cross-coupling reaction of aryl/heteroaryl and alkenyl mesylates and tosylates with aryl titanium as the multi-functional reagent is reported. Using the catalyst system of Pd(OAc)2 associated with the new NMe2-CM-Phos (L14), a broad range of electron-rich, electron-neutral, electron-deficient, and sterically hindered aryl/heteroaryl and alkenyl mesylates and tosylates are well coupled with aryl titanium reagents to give the corresponding products in good to excellent yields. The catalyst loading down to 0.2 mol% Pd and the reaction time shortening to 10 min can be achieved. The reaction can be easily scaled up to the gram scale without diminishing the product yield.
Original language | English |
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Pages (from-to) | 926-932 |
Number of pages | 7 |
Journal | Organic Chemistry Frontiers |
Volume | 7 |
Issue number | 7 |
DOIs | |
Publication status | Published - 7 Apr 2020 |
ASJC Scopus subject areas
- Organic Chemistry