Pain Symptoms in Optic Neuritis

Xiayin Yang, Xuefen Li, Mengying Lai, Jincui Wang, Shaoying Tan (Corresponding Author), Henry Ho-lung Chan (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Signs and symptoms of optic neuritis (ON), an autoimmune disorder of the central nervous system (CNS), differ between patients. Pain, which is commonly reported by ON patients, may be the major reason for some patients to visit the clinic. This article reviews the presence of pain related to ON with respect to underlying disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein associated disease (MOGAD). The aim of this review is to provide an overview of pain symptoms in accordance with the context of various pathophysiological explanations, assist in differential diagnosis of ON patients, especially at the onset of disease, and make recommendations to aid physicians make decisions for follow up diagnostic examinations.
Original languageEnglish
Article number865302
Pages (from-to)1-13
Number of pages13
JournalFrontiers in Pain Research
Publication statusPublished - 14 Apr 2022


  • pain
  • optic neuritis
  • mechanism
  • treatment
  • multiple sclerosis
  • Neuromyelitis optica spectrum disorders
  • myelin oligodendrocyte glycoprotein associated disease


Dive into the research topics of 'Pain Symptoms in Optic Neuritis'. Together they form a unique fingerprint.

Cite this