Pain controlling and Cytokine-regulating effects of lyprinol, a lipid extract of perna canaliculus, in a rat Adjuvant-induced arthritis model

Chi Ho Lee, John Hon Kei Lum, Curtise Kin Cheung Ng, Janice McKay, Yoki Kwok Chu Butt, Man Sau Wong, Chun Lap Samuel Lo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

15 Citations (Scopus)


Using an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract of Perna canaliculus (Lyprinol®) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol® to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol® after day 914. The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol® decreased the levels of the pro-inflammatory cytokines TNF-α and IFN-γ, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol® were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract of P. canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.
Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalEvidence-based Complementary and Alternative Medicine
Issue number2
Publication statusPublished - 1 Jun 2009


  • Adjuvant-induced arthritis
  • Inflammatory cytokines
  • Lyprinol®
  • NZGLM, pain score

ASJC Scopus subject areas

  • Complementary and alternative medicine

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